Stay tuned for the first lab publications!
2025
Alba Alfonso-Garcia, Julien Bec, Mohamed Hassan, Silvia Anbunesan, Lisanne Kraft, Matthew Bobinski, Lee-Way Jin, Han Sung Lee, Griffith R Harsh, Orin Bloch, Laura Marcu, “Label-free fluorescence lifetime imaging for real-time guidance of stereotactic biopsy: A feasibility study in brain cancer patients” (under review at Neuro-Oncology)
Liu, X., Bec, J., Zhou, X., Alba Alfonso-Garcia. & Laura Marcu “Multispectral laser-scanning pulse-sampling fluorescence lifetime system for large-scale tissue imaging.” Opt. Lett. (2025) doi:10.1364/ol.547582.
Dattesh R. Dave, Alba Alfonso-Garcia, Lisanne Kraft, Laura Marcu, & Clifford T. Pereira “Defining the Zone of Acute Peripheral Nerve Injury Using Fluorescence Lifetime Imaging in a Crush Injury Sheep Model.” J. Hand Surg. (2025) doi:10.1016/j.jhsa.2024.11.020.
2024
Alba Alfonso-Garcia, Lisanne Kraft, Xiagnan Zhou, Julien Bec, Laura Marcu, Dongguang Wei, Shiro Urayama, Asha Cogdill. “Colorectal Polyp Assessment with Label-Free Fluorescence Lifetime Imaging.” Opt. Biophotonics Congr.: Biomed. Opt. 2024 (Transl., Microsc., OCT, OTS, BRAIN) TM3B.2 (2024) doi:10.1364/translational.2024.tm3b.2.
Alba Alfonso-Garcia. et al. Empowering Women in Biomedical Engineering: A Departmental Pathway to Inclusion and Support. Biophys. (2024) doi:10.35459/tbp.2023.000259.
Thomas Knapp, Suzann Duan, Alba Alfonso-Garcia, Juanita L. Merchant, Travis W. Sawyer. “Validation of label-free optical imaging markers of pancreatic cancer using spatial transcriptomics.” Label-free Biomed. Imaging Sens. (LBIS) 2024 12854, 1285407-1285407–14 (2024).
2023
Alba Alfonso-Garcia, Silvia Noble Anbunesan, Julien Bec, Han Sung Lee, Lee-Way Jin, Orin Bloch, Laura Marcu “In vivo characterization of the human glioblastoma infiltrative edge with label-free intraoperative fluorescence lifetime imaging”. Biomed. Opt. Express 14, 2196 (2023). doi: https://doi.org/10.1364/BOE.481304.
Xiangnan Zhou, Julien Bec, Katjana Ehrlich, Alba Alfonso-Garcia, Laura Marcu “Pulse-sampling fluorescence lifetime imaging: evaluation of photon economy.” Opt. Lett. 48, 4578 (2023). doi: https://doi.org/10.1364/OL.490096 .
2022
Silvia Noble Anbunesan, Alba Alfonso‐Garcia, Xiangnan Zhou, Julien Bec, Han Sung Lee, Lee‐Way Jin, Orin Bloch, Laura Marcu “Intraoperative detection of IDH‐mutant glioma using fluorescence lifetime imaging”. J Biophotonics e202200291 (2022) doi:10.1002/jbio.202200291.
Alba Alfonso-Garcia, Stephanie A. Cevallos, Jee-Yon Lee, Cai Li, Julien Bec, Andreas J. Bäumler, Laura Marcu“Assessment of murine colon inflammation using intraluminal fluorescence lifetime imaging”. molecules 1317 (2022). Ed. by Anna Cleta Croce, p. 14. doi: https://doi.org/10.3390/molecules27041317.
Alba Alfonso-García, Xiangnan Zhou, Julien Bec, Silvia Noble Anbunesan, Farzad Fereidouni, Lee-Way Jin, Han S. Lee, Orin Bloch, Laura Marcu “First in patient assessment of brain tumor infiltrative margins using simultaneous time-resolved measurements of 5-ALA-induced PpIX fluorescence and tissue autofluorescence”. Journal of Biomedical Optics 27 (2022), p. 20501. issn: 1083-3668. doi: 10.1117/1.jbo.27.2.020501.
2021
Alba Alfonso‐Garcia, Julien Bec, Brent Weyers, Mark Marsden, Xiangnan Zhou, Cai Li, Laura Marcu “Mesoscopic fluorescence lifetime imaging: Fundamental principles, clinical applications and future directions”. Journal of Biophotonics (2021), e202000472. issn: 1864-063X. doi: 10.1002/jbio.202000472.
2020
Julien Bec, Tanveer Ahmed Shaik, Christoph Krafft, Thomas W Bocklitz, Alba Alfonso-Garcia, Kenneth B Margulies, Jürgen Popp, Laura Marcu “Investigating Origins of FLIm Contrast in Atherosclerotic Lesions Using Combined FLIm-Raman Spectroscopy”. Frontiers in Cardiovascular Medicine 7 (2020), p. 122. doi: 10.3389/fcvm.2020.00122.
Tanveer Ahmed Shaik, Alba Alfonso-Garcia, Martin Richter, Florian Korinth, Christoph Krafft, Laura Marcu, Jürgen Popp “FLIm and Raman Spectroscopy for Investigating Biochemical Changes of Bovine Pericardium upon Genipin Cross-Linking”. molecules 25 (2020), p. 3857. doi: 10.3390/molecules25173857.
Tanveer Ahmed Shaik, Alba Alfonso-García, Xiangnan Zhou, Katherine M Arnold, Anne K Haudenschild, Christoph Krafft, Leigh G Griffiths, Jürgen Popp, Laura Marcu “FLIm-Guided Raman Imaging to Study Cross-Linking and Calcification of Bovine Pericardium.” Analytical chemistry (2020). issn: 0003-2700. doi: 10.1021/acs.analchem.0c01772.
Nelda Vazquez-Portalatin, Alba Alfonso-Garcia, Julie C. Liu, Laura Marcu, Alyssa Panitch “Physical, Biomechanical, and Optical Characterization of Collagen and Elastin Blend Hydrogels”. Annals of Biomedical Engineering (2020), pp. 1–12. issn: 0090-6964. doi: 10.1007/s10439-020-02605-x.
2019
Alba Alfonso‐Garcia, Julien Bec, Shamira Sridharan Weaver, Brad Hartl, Jakob Unger, Matthew Bobinski, Mirna Lechpammer, Fady Girgis, James Boggan, Laura Marcu “Real-time augmented reality for delineation of surgical margins during neurosurgery using autofluorescence lifetime contrast”. Journal of Biophotonics (2019), e201900108. issn: 1864-063X. doi: 10.1002/jbio.201900108.
Alba Alfonso-Garcia, Cai Li, Julien Bec, Diego Yankelevich, Laura Marcu, Ben Sherlock “Fiber-based platform for synchronous imaging of endogenous and exogenous fluorescence of biological tissue”. Optics Letters 44 (2019), p. 3350. issn: 0146-9592. doi: 10.1364/ol.44.003350.
Cai Li, Alba Alfonso-Garcia, James McMasters, Julien Bec, Brent Weyers, Lauren Uyesaka, Leigh Griffiths, Alyssa Panitch, Laura Marcu “Simultaneous intraluminal imaging of tissue autofluorescence and eGFP-labeled cells in engineered vascular grafts inside a bioreactor”. Methods and Applications in Fluorescence 7 (2019), p. 44003. issn: 2050-6120. doi: 10.1088/2050- 6120/ab4342.
Benjamin E Sherlock, Cai Li, Xiangnan Zhou, Alba Alfonso-Garcia, Julien Bec, Diego Yankelevich, Laura Marcu “Multiscale, multispectral fluorescence lifetime imaging using a double-clad fiber”. Optics Letters 44 (2019), p. 2302. issn: 0146-9592. doi: 10.1364/ol.44.002302.
Jeny Shklover, James McMasters, Alba Alfonso-Garcia, Manuela Lopera Higuita, Alyssa Panitch, Laura Marcu, Leigh Griffiths “Bovine pericardial extracellular matrix niche modulates human aortic endothelial cell phenotype and function”. Scientific Reports 9 (2019), p. 16688. doi: 10.1038/s41598-019-53230-1.
2018
Alba Alfonso-Garcia, Anne K Haudenschild, and Laura Marcu. “Label-free assessment of carotid artery biochemical composition using fiber-based fluorescence lifetime imaging”. Biomedical Optics Express 9 (2018), p. 4064. issn: 2156-7085. doi: 10.1364/boe.9.004064.
Alba Alfonso-Garcia, Jeny Shklover, Benjamin E. Sherlock, Alyssa Panitch, Leigh G. Griffiths, Laura Marcu “Fiber-based fluorescence lifetime imaging of recellularization processes on vascular tissue constructs”. Journal of Biophotonics 11 (2018), e201700391. doi: 10.1002/jbio.201700391.
Jacob E. Friedman, Evgenia Dobrinskikh, Alba Alfonso‐Garcia, Alexander Fast, Rachel C. Janssen, Taylor K. Soderborg, Aimee L. Anderson, Julie A. Reisz, Angelo D'Alessandro, Daniel N. Frank, Charles E. Robertson, Becky A. de la Houssaye, Linda K. Johnson, David J. Orlicky, Xiaoxin X. Wang, Moshe Levi, Eric O. Potma, Karim C. El Kasmi, Karen R. Jonscher “Pyrroloquinoline quinone prevents developmental programming of microbial dysbiosis and macrophage polarization to attenuate liver fibrosis in offspring of obese mice”. Hepatology Communications 2 (2018), pp. 313–328. issn: 2471-254X. doi: 10.1002/hep4.1139.
Cai Li, Jeny Shklover, Mojtaba Parvizi, Benjamin E. Sherlock, Alba Alfonso-Garcia, Anne K. Haudenschild, Leigh G. Griffiths, Laura Marcu “Label-Free Assessment of Collagenase Digestion on Bovine Pericardium Properties by Fluorescence Lifetime Imaging”. Annals of Biomedical Engineering 46 (2018), pp. 1870–1881. doi: 10.1007/s10439-018-2087-6.
Jerry R. Paugh, Alba Alfonso-Garcia, Andrew Loc Nguyen, Jeffrey L. Suhalim, Marjan Farid, Sumit Garg, Jeremiah Tao, Donald J. Brown, Eric O. Potma, James V. Jester “Characterization of expressed human meibum using hyperspectral stimulated Raman scattering microscopy”. The Ocular Surface (2018). issn: 1542-0124. doi: 10.1016/j.jtos.2018.10.003.
2017
Alba Alfonso‐García, Jerry Paugh, Marjan Farid, Sumit Garg, James Jester, Eric Potma “A machine learning framework to analyze hyperspectral stimulated Raman scattering microscopy images of expressed human meibum”. Journal of Raman Spectroscopy 48 (2017). issn: 10974555. doi: 10.1002/jrs.5118.
2016
Alba Alfonso-García, Simon G. Pfisterer, Howard Riezman, Elina Ikonen, Eric O. Potma “D38-cholesterol as a Raman active probe for imaging intracellular cholesterol storage”. Journal of Biomedical Optics 21 (2016), p. 61003. issn: 1083-3668. doi: 10.1117/1.jbo.21.6.061003.
Alba Alfonso-García, Tim D. Smith, Rupsa Datta, Thuy U. Luu, Enrico Gratton, Eric O. Potma, Wendy F. Liu “Label-free identification of macrophage phenotype by fluorescence lifetime imaging microscopy”. In: Journal of Biomedical Optics 21 (2016), p. 46005. issn: 1083-3668. doi: 10.1117/1.jbo.21.4.046005.
Kevin T Crampton, Aram Zeytunyan, Alexander S Fast, Faezeh T Ladani, Alba Alfonso-Garcia, Mayukh Banik, Steven Yampolsky, Dmitry A Fishman, Eric O Potma, V Ara Apkarian “Ultrafast Coherent Raman Scattering at Plasmonic Nanojunctions”. The Journal of Physical Chemistry C 120 (2016), pp. 20943– 20953. issn: 1932-7447. doi: 10.1021/acs.jpcc.6b02760.
Karen R. Jonscher, Michael S. Stewart, Alba Alfonso-Garcia, Brian C. DeFelice, Xiaoxin X. Wang, Yuhuan Luo, Moshe Levi, Margaret J. R. Heerwagen, Rachel C. Janssen, Becky A. de la Houssaye, Ellen Wiitala, Garrett Florey, Raleigh L. Jonscher, Eric O. Potma, Oliver Fiehn, Jacob E. Friedman “Early PQQ supplementation has persistent long-term protective effects on developmental programming of hepatic lipotoxicity and inflammation in obese mice”. The FASEB Journal 31 (2016), pp. 1434–1448. issn: 0892-6638. doi: 10.1096/fj.201600906r.
Karen R. Jonscher, Alba Alfonso-Garcia, Jeffrey L. Suhalim, David J. Orlicky, Eric O. Potma, Virginia L. Ferguson, Mary L. Bouxsein, Ted A. Bateman, Louis S. Stodieck, Moshe Levi, Jacob E. Friedman, Daila S. Gridley, Michael J. Pecaut “Spaceflight Activates Lipotoxic Pathways in Mouse Liver”. PLOS ONE 11 (2016), e0152877. doi: 10.1371/journal.pone. 0152877.
2015
Rupsa Datta, Alba Alfonso-García, Rachel Cinco, Enrico Gratton “Fluorescence lifetime imaging of endogenous biomarker of oxidative stress”. Scientific Reports 5 (2015), srep09848. issn: 2045-2322. doi: 10.1038/srep09848.
Kimberley L. Gallagher, Alba Alfonso-Garcia, Jessica Sanchez, Eric O. Potma, Guaciara M. Santos “Plant growth conditions alter phytolith carbon”. Frontiers in Plant Science 6 (2015), p. 753. doi: 10.3389/fpls.2015. 00753.
2014
Alba Alfonso-García, Richa Mittal, Eun Seong Lee, Eric O. Potma “Biological imaging with coherent Raman scattering microscopy: a tutorial”. Journal of Biomedical Optics 19 (2014), p. 71407. issn: 1083-3668. doi: 10.1117/1.jbo.19.7.071407.
Ursula Loizides-Mangold, Sophie Clément, Alba Alfonso-Garcia, Emilie Branche, Stéphanie Conzelmann, Clotilde Parisot, Eric O. Potma, Howard Riezman, Francesco Negro “HCV 3a Core Protein Increases Lipid Droplet Cholesteryl Ester Content via a Mechanism Dependent on Sphingolipid Biosynthesis”. PLoS ONE 9 (2014), e115309. doi: 10.1371/journal.pone.0115309.